Table 2 Optimized multivariate immune profiles for predicting COVID-19 disease severity using discriminant analysis.

From: Multivariate indicators of disease severity in COVID-19

 

Wilks’ λ

p-value/corrected p-value

Standardized canonical discriminant function coefficient

1st discriminant function

2nd discriminant function

Model 1

 NK cells

0.351

1.11 × 10−8/1.89 × 10−6

0.886

0.019

 ActSMB

0.559

3.84 × 10−5/6.21 × 10−3

 − 0.049

1.242

 T cells

0.418

2.33 × 10−7/3.96 × 10−5

0.706

 − 0.176

 ActNeut

0.907

0.181/1

 − 0.042

0.825

 ImGran

0.953

0.432/1

 − 0.451

0.437

Model 2

 MAIT

0.459

1.434 × 10−7/2.44 × 10−5

1.024

N/A

 En38NK

0.960

2.31 × 10−3/0.365

0.968

N/A

 ActNB

0.852

0.017/1

0.984

N/A

 En27NK

0.993

0.629/1

 − 0.626

N/A

 Temra

0.908

0.063/1

 − 0.443

N/A

Model 3

 Monocyte HLA-DR MFI

0.413

3.17 × 10−6/5.42 × 10−4

0.616

N/A

 ActSMB

0.597

3.72 × 10−4/0.0617

1.415

N/A

 NK cells

0.420

3.90 × 10−6/6.63 × 10−4

1.199

N/A

 CXCR5+ CD8+ MAIT

0.997

0.786/1

1.493

N/A

 cDC HLA-DR MFI

0.952

0.271/1

0.944

N/A

 Temra

1.000

0.998/1

 − 1.137

N/A

 Neutrophils

0.681

2.14 × 10−3/0.352

 − 0.622

N/A

  1. Discriminant models were constructed to distinguish between healthy volunteers, moderately ill patients, and severely ill patients (Model 1); healthy volunteers and COVID-19 patients presenting with moderate or severe disease (Model 2); or moderately ill and severely ill COVID-19 patients (Model 3). Model variables are listed in the order they were incorporated into the model. Correction for multiple testing was performed using Holm method60.
  2. NK cells natural killer cells, en27NK CD27+ NK cells, en38NK CD38+ NK cells, actNeut activated HLA-DR+ neutrophils, imGran Ki67+ immature granulocytes, Temra CD27−CD45RA+ effector memory CD8+ T cells, actNB CD21+CD27−Ki67+ B cells, actSMB CD21−CD27+CD38lo B cells.
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