Figure 4
From: Mechanism of ferroptosis in a rat model of premature ovarian insufficiency induced by cisplatin
Effects of CDDP and VE on ferroptosis in ovarian tissue. (A, E) Perls staining of ovarian tissues in each group, and Fe3+ blue positive areas were calculated using image J computing software. Scale bar 200 μm. (B, C, D) Transmission electron microscopy was used to observe the mitochondrial ultrastructure in GCs in the ovary tissues of each group. (F) MDA expression levels in ovarian tissues of each group. Data are expressed as the means ± SEM. n = 20, ns, * versus control, *P < 0.05, **P < 0.01, ***P < 0.001 and ****P < 0.0001, ns indicates no statistical significance. N, # versus CDDP + VE, # P < 0.05, ## P < 0.01, ###P < 0.001 and #### P < 0.0001, N indicates no statistical significance.
