Table 2 Demographic characteristics of the target data (ADc12 and GenADA) with APOE SNP genotyping.
From: Genetic correlations between Alzheimer’s disease and gut microbiome genera
Discovery Sample (ADc12) | Replication Sample (GenADA) | |||||||
|---|---|---|---|---|---|---|---|---|
Cases | Controls | Total | Cases | Controls | Total | |||
Age, mean ± SD | 1278 | 1293 | 2571 | 799 | 778 | 1577 | ||
76.57 ± 6.71* | 70.27 ± 10.29 | 72.24 ± 8.41** | 73.40 ± 7.92 | |||||
Sex (Male/Female) | 443/835 | 471/822 | 914/1657 | 339/460 | 276/502 | 615/962 | ||
APOE SNP Genotype | rs429358 | T/T, n(%) | 409 (32.0) | 847 (65.5) | 1256 (48.9) | 296 (37.0) | 589 (75.7) | 885 (56.1) |
T/C, n(%) | 682 (53.4) | 414 (32.0) | 1096 (42.6) | 397 (49.7) | 177 (22.8) | 574 (36.4) | ||
C/C, n(%) | 187 (14.6) | 32 (2.5) | 219 (8.5) | 106 (13.3) | 12 (1.5) | 118 (7.5) | ||
C/C, n(%) | 1206 (94.4) | 1128 (87.2) | 2334 (90.8) | 739 (92.5) | 661 (85.0) | 1400 (88.8) | ||
rs7412 | C/T, n(%) | 71 (5.6) | 159 (12.3) | 230 (8.9) | 60 (7.5) | 113 (14.5) | 173 (11.0) | |
T/T, n(%) | 1 (0.0) | 6 (5.1) | 7 (0.3) | 0 (0.0) | 4 (0.5) | 4 (0.3) | ||
