Table 5 List of gut microbiome genera that were nominally associated with APOE SNPs rs429358 and rs7412.

From: Genetic correlations between Alzheimer’s disease and gut microbiome genera

rsID (CHR:BP:Effect Allele)

Microbiome Genera

Beta

SE

SZ

P

N

# cohorts

rs429358 (19:45411941:C)

Bacteroides

− 0.044

0.015

− 2.881

0.0040

18173

23

Butyricimonas

− 0.044

0.020

− 2.241

0.0250

10657

23

Dorea

0.030

0.015

2.127

0.0334

17494

23

Eubacterium coprostanoligenes

0.033

0.015

2.120

0.0340

17261

23

Faecalibacterium

− 0.035

0.015

− 2.188

0.0287

17960

23

Olsenella

0.064

0.033

1.993

0.0462

3721

13

Parasutterella

0.040

0.019

2.216

0.0267

11291

23

Senegalimassilia

0.050

0.024

2.207

0.0273

6888

21

Veillonella

0.044

0.021

2.032

0.0421

9194

23

rs7412 (19:45412079:T)

Butyricicoccus

0.048

0.021

2.468

0.0136

15637

20

Collinsella

0.052

0.023

2.214

0.0268

12811

19

Coprococcus3

0.050

0.022

2.344

0.0191

14323

20

Eubacterium hallii

0.053

0.021

2.453

0.0142

14846

20

Lachnospiraceae UCG001

− 0.071

0.027

− 2.534

0.0113

9357

20

Olsenella

− 0.103

0.043

− 2.346

0.0190

3721

13

Ruminococcaceae UCG004

0.080

0.028

2.901

0.0037

9049

20

Senegalimassilia

0.082

0.032

2.584

0.0098

6508

18

  1. SNP data were extracted from GWAS summary statistics of human gut microbiome abundance conducted from 24 multi-ethnic cohorts in the MiBioGen consortium (www.mibiogen.org)24. rsID (CHR:BP:Effect Allele): the rs number of single nucleotide polymorphisms, chromosome number (CHR), base pair (BP), with the effect allele (genome assembly GRCh37/hg19). Microbiome: the genus level with significant abundance associated with APOE two SNPs. Beta: Beta coefficient. SE: Standard Error. SZ: Weighted sum of z-scores. P: p-value (p < 0.05 was considered as nominal association between the microbiome genera and APOE). N: sample count. # Cohorts: Number of cohorts involved.
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