Table 2 Associations of aspirin alone compared to aspirin plus statin with the risk of total CVD.

From: Cardiovascular disease preventive effects of aspirin combined with different statins in the United States general population

CVD medications

Model 1

Model 2

Model 3

OR (95% CI)

OR (95% CI)

OR (95% CI)

Aspirin alone

Ref.

Ref.

Ref.

Atorvastatin and aspirin combination

0.36 (0.30, 0.44)***

0.36 (0.28, 0.45)***

0.43 (0.33, 0.57)***

Lovastatin and aspirin combination

0.55 (0.38, 0.80)**

0.65 (0.42, 1.01)

0.69 (0.42, 1.13)

Pravastatin and aspirin combination

0.40 (0.31, 0.52)***

0.43 (0.31, 0.58)***

0.44 (0.31, 0.62)***

Rosuvastatin and aspirin combination

0.31 (0.23, 0.41)***

0.34 (0.25, 0.48)***

0.34 (0.23, 0.50)***

Simvastatin and aspirin combination

0.53 (0.43, 0.64)***

0.54 (0.43, 0.68)***

0.64 (0.49, 0.84)**

  1. Model 1: age and gender. Model 2: Model 1 variables plus education level, race/ethnicity, family poverty-income ratio, hypertension, diabetes mellitus, smoker, alcohol user, and body mass index. Model 3 was adjusted for Model 2 variables plus physical activity, total energy intake, high-density lipoprotein-cholesterol, total cholesterol, triglyceride, uric acid, creatinine, blood urea nitrogen, and hemoglobin.
  2. CVD cardiovascular disease, OR odd ratio, CI confidence interval.
  3. **P < 0.01, ***P < 0.001.
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