Table 3 Associations of aspirin alone compared to aspirin plus statin with the risk of individual CVD.

From: Cardiovascular disease preventive effects of aspirin combined with different statins in the United States general population

CVD medications

CHF

CHD

Angina

Heart attack

Stroke

OR (95% CI)

OR (95% CI)

OR (95% CI)

OR (95% CI)

OR (95% CI)

Aspirin alone

1.00

1.00

1.00

1.00

1.00

Atorvastatin and aspirin combination

0.51 (0.34, 0.77)**

0.28 (0.19, 0.39)***

0.37 (0.23, 0.59)***

0.37 (0.26, 0.54)***

0.90 (0.60, 1.35)

Lovastatin and aspirin combination

0.91 (0.39, 2.13)

0.50 (0.26, 0.96)*

0.64 (0.26, 1.60)

0.74 (0.368, 1.482)

0.63 (0.33, 1.22)

Pravastatin and aspirin combination

0.60 (0.36, 1.02)

0.38 (0.24, 0.60)***

0.34 (0.19, 0.60)***

0.47 (0.297, 0.749)***

0.58 (0.36, 0.92)*

Rosuvastatin and aspirin combination

0.47 (0.27, 0.84)*

0.24 (0.15, 0.39)***

0.24 (0.13, 0.42)***

0.30 (0.189, 0.488)***

0.98 (0.54, 1.81)

Simvastatin and aspirin combination

0.65 (0.42, 0.99)*

0.40 (0.28, 0.57)***

0.42 (0.26, 0.67)***

0.48 (0.334, 0.685)***

1.07 (0.71, 1.62)

  1. Analysis was adjusted for age, gender, education level, race/ethnicity, marital status, family poverty-income ratio, hypertension, diabetes mellitus, smoker, alcohol user, body mass index, physical activity, total energy intake, high-density lipoprotein-cholesterol, total cholesterol, triglyceride, uric acid, creatinine, blood urea nitrogen, and hemoglobin.
  2. CVD cardiovascular disease, CHF congestive heart failure, CHD coronary heart disease, OR odd ratio, CI confidence interval.
  3. *P < 0.05, **P < 0.01, ***P < 0.001  .
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