Figure 7

Photomicrograph of haematoxylin and eosin-stained sections from hippocampus of obese male rat (a–c) and obese female rat (d–f), where; (a) showing areas of small pyramidal neurons loss; some have pyknotic (P) and others have karyorrhectic (_*) nuclei with vacuolation (V); (b) disorganization and extensive damage with apoptosis of most large pyramidal neurons (↑) with vacuolation (V); (c) granular cell layers (|) showed cell loss with marked vacuolations. Molecular layer (ML) shows marked enlargement of pyramidal (↕) and glial cells (wavy arrow); (d) showing areas of small pyramidal cells loss; some have pyknotic (P) and others have karyorrhectic (_*) nuclei with vacuolation (V); (e) disorganization and extensive damage with apoptosis of many large pyramidal cells (↑) with few normal cells (right pointing triangle); (f) granular cell layers (|) showed cell loss with less vacuolation compared to males. Molecular layer (ML) shows marked enlargement of pyramidal (↕) and glial cells (wavy arrow) (H & E, ×400).