Table 2 Comparison of T and B-cell subsets percentages in SjS and Sicca groups.

From: Added value of lymphocyte subpopulations in the classification of Sjögren's syndrome

Lymphocyte subsets or combinations

Cells %, median (25–75th percentile)

SjS

n = 62

Sicca

n = 63

SjS vs Sicca

p values

Lymphocytes

30.6 (11.0)*

31.4 (8.7)*

0.745

 T-cells

75.0 (68.2, 78.0)

72.2 (67.6, 77.0)

0.185

  CD4+

61.2 (53.7, 68.1)

65.9 (60.3, 70.0)

0.009

  CD8+

38.9 (11.4)*

34.0 (9.1)*

0.012

 B-cells

10.2 (7.5, 14.1)

11.2 (8.5, 14.6)

0.411

T-cells' subpopulations

 Th1

38.7 (29.7, 45.6)

40.4 (30.2, 47.4)

0.555

 Th17

19.8 (14.2, 28.4)

22.3 (16.6, 28.6)

0.293

 Treg

8.4 (6.6, 10.0)

7.6 (6.9, 8.7)

0.059

 Tfh (CXCR5+CD4+)

19.4 (5.8)*

18.4 (4.7)*

0.397

  Tfh1

35.4 (7.8)*

32.3 (6.9)*

0.025

  Tfh17

21.9 (6.6)*

23.2 (5.6)*

0.165

 Tfc (CXCR5+CD8+)

2.6 (1.9, 4.2)

2.63 (1.88, 4.07)

0.865

B-cell's subpopulations

 IgD/CD27

  Naive

68.5 (52.5, 77.7)

66.6 (48.6, 75.1)

0.369

  Memory

29.3 (20.0, 44.1)

31.4 (23.3, 45.2)

0.239

   Unswitched

13.6 (8.9, 21.6)

17.5 (11.2, 24.5)

0.084

   Switched

14.4 (9.7, 21.9)

14.7 (10.9, 21.6)

0.724

 Bm1–5

  Bm1

10.0 (5.6, 14.9)

13.9 (8.1, 19.5)

0.003

  Bm2

61.4 (49.9, 67.2)

59.8 (47.5, 66.5)

0.673

  Bm2'

8.5 (5.9) *

5.9 (3.3) *

0.046

  Bm3 + Bm4

1.34 (0.93, 3.28)

1.36 (0.87, 1.85)

0.348

  eBm5

8.5 (6.1, 12.5)

8.6 (6.3, 12.6)

0.841

  Bm5

6.9 (4.4, 12.4)

7.8 (5.1, 10.6)

0.927

  Bm2 + Bm2'

71.2 (56.2, 79.2)

67.1 (52.0, 73.4)

0.146

  eBm5 + Bm5

16.8 (10.8, 24.9)

16.7 (12.4, 25.2)

0.884

  Bm2 + Bm2'/Bm5 + eBm5

3.9 (2.2, 7.2) *

4.1 (2.0, 5.9) *

0.641

 CD24hiCD38hi

5.6 (2.2, 8.5) *

4.1 (2.7, 5.3) *

0.061

 CD24hiCD27+

16.9 (12.2, 25.4)

21.3 (14.3, 35.4)

0.024

T-cell/B-cell ratios

 Th1/CD24hiCD27+

2.23 (1.22, 3.60)

1.60 (1.09, 2.70)

0.033

 Th17/Tregs

0.26 (0.18, 0.40)

0.35 (0.22, 0.44)

0.021

  1. Bold numbers represent significance (p-values < 0.05) or relevance (p-values < 0.100); SjS, Sjogren’s syndrome.
  2. *indicates Mean and Standard Deviation.