Table 2 Comparison of T and B-cell subsets percentages in SjS and Sicca groups.
From: Added value of lymphocyte subpopulations in the classification of Sjögren's syndrome
Lymphocyte subsets or combinations Cells %, median (25–75th percentile) | SjS n = 62 | Sicca n = 63 | SjS vs Sicca p values |
|---|---|---|---|
Lymphocytes | 30.6 (11.0)* | 31.4 (8.7)* | 0.745 |
T-cells | 75.0 (68.2, 78.0) | 72.2 (67.6, 77.0) | 0.185 |
CD4+ | 61.2 (53.7, 68.1) | 65.9 (60.3, 70.0) | 0.009 |
CD8+ | 38.9 (11.4)* | 34.0 (9.1)* | 0.012 |
B-cells | 10.2 (7.5, 14.1) | 11.2 (8.5, 14.6) | 0.411 |
T-cells' subpopulations | |||
Th1 | 38.7 (29.7, 45.6) | 40.4 (30.2, 47.4) | 0.555 |
Th17 | 19.8 (14.2, 28.4) | 22.3 (16.6, 28.6) | 0.293 |
Treg | 8.4 (6.6, 10.0) | 7.6 (6.9, 8.7) | 0.059 |
Tfh (CXCR5+CD4+) | 19.4 (5.8)* | 18.4 (4.7)* | 0.397 |
Tfh1 | 35.4 (7.8)* | 32.3 (6.9)* | 0.025 |
Tfh17 | 21.9 (6.6)* | 23.2 (5.6)* | 0.165 |
Tfc (CXCR5+CD8+) | 2.6 (1.9, 4.2) | 2.63 (1.88, 4.07) | 0.865 |
B-cell's subpopulations | |||
IgD/CD27 | |||
Naive | 68.5 (52.5, 77.7) | 66.6 (48.6, 75.1) | 0.369 |
Memory | 29.3 (20.0, 44.1) | 31.4 (23.3, 45.2) | 0.239 |
Unswitched | 13.6 (8.9, 21.6) | 17.5 (11.2, 24.5) | 0.084 |
Switched | 14.4 (9.7, 21.9) | 14.7 (10.9, 21.6) | 0.724 |
Bm1–5 | |||
Bm1 | 10.0 (5.6, 14.9) | 13.9 (8.1, 19.5) | 0.003 |
Bm2 | 61.4 (49.9, 67.2) | 59.8 (47.5, 66.5) | 0.673 |
Bm2' | 8.5 (5.9) * | 5.9 (3.3) * | 0.046 |
Bm3 + Bm4 | 1.34 (0.93, 3.28) | 1.36 (0.87, 1.85) | 0.348 |
eBm5 | 8.5 (6.1, 12.5) | 8.6 (6.3, 12.6) | 0.841 |
Bm5 | 6.9 (4.4, 12.4) | 7.8 (5.1, 10.6) | 0.927 |
Bm2 + Bm2' | 71.2 (56.2, 79.2) | 67.1 (52.0, 73.4) | 0.146 |
eBm5 + Bm5 | 16.8 (10.8, 24.9) | 16.7 (12.4, 25.2) | 0.884 |
Bm2 + Bm2'/Bm5 + eBm5 | 3.9 (2.2, 7.2) * | 4.1 (2.0, 5.9) * | 0.641 |
CD24hiCD38hi | 5.6 (2.2, 8.5) * | 4.1 (2.7, 5.3) * | 0.061 |
CD24hiCD27+ | 16.9 (12.2, 25.4) | 21.3 (14.3, 35.4) | 0.024 |
T-cell/B-cell ratios | |||
Th1/CD24hiCD27+ | 2.23 (1.22, 3.60) | 1.60 (1.09, 2.70) | 0.033 |
Th17/Tregs | 0.26 (0.18, 0.40) | 0.35 (0.22, 0.44) | 0.021 |