Table 5 Cox regression—cancer specific survival.
Univariate | Multivariable | |||||
|---|---|---|---|---|---|---|
Hazard ratio | 95% CI | p-value | Hazard ratio | 95% CI | p-value | |
Gender | ||||||
Female | Reference | Reference | Reference | Reference | ||
Male | 1.90 | (1.19–3.03) | 0.007** | 1.93 | (1.15–3.23) | 0.012* |
Age | 1.03 | (1.00–1.05) | 0.022* | 1.04 | (1.01–1.07) | 0.005** |
GNRI | ||||||
≥ 92 | Reference | Reference | Reference | Reference | ||
< 92 | 6.14 | (3.84–9.82) | < 0.001** | 5.42 | (3.24–9.06) | < 0.001** |
Performance status ECOG | ||||||
0 | Reference | Reference | ||||
1 | 0.48 | (0.27–0.88) | 0.588 | |||
2–4 | 1.00 | (0.50–1.99) | 0.996 | |||
Comorbidity | ||||||
HTN | 1.09 | (0.67–1.77) | 0.720 | |||
DM | 1.05 | (0.59–1.86) | 0.867 | |||
COPD/asthema | 1.66 | (0.52–5.28) | 0.390 | |||
CAD | 1.52 | (0.55–4.16) | 0.418 | |||
Creatinine > 1.5 mg/dL | 1.47 | (0.89–2.41) | 0.130 | |||
Smoking status | ||||||
Never | Reference | Reference | ||||
Current/former | 1.56 | (0.96–2.54) | 0.073 | |||
Preoperative renal function | ||||||
eGFR ≥ 30 ml/min/1.73m2 | Reference | Reference | ||||
eGFR < 30 ml/min/1.73m2 | 0.79 | (0.44–1.42) | 0.435 | |||
History of uremia | ||||||
Negative | Reference | Reference | ||||
Positive | 0.55 | (0.24–1.27) | 0.163 | |||
Surgical margin | ||||||
Negative | Reference | Reference | Reference | Reference | ||
Positive | 8.31 | (5.15–13.41) | < 0.001** | 2.16 | (1.26–3.71) | 0.005** |
Pathological T | ||||||
T1 | Reference | Reference | Reference | Reference | ||
T2 | 3.26 | (1.03–10.29) | 0.044* | 2.38 | (0.72–7.81) | 0.154 |
T3 | 10.21 | (4.54–22.96) | < 0.001** | 6.30 | (2.57–15.43) | < 0.001** |
T4 | 56.80 | (24.07–134.02) | < 0.001** | 24.79 | (8.21–74.87) | < 0.001** |
Pathological N | ||||||
N0 | Reference | Reference | Reference | Reference | ||
N1 | 6.23 | (2.93–13.24) | < 0.001** | 1.50 | (0.65–3.47) | 0.344 |
N2–3 | 11.39 | (6.60–19.64) | < 0.001** | 1.23 | (0.59–2.55) | 0.577 |
Tumor grade | ||||||
Low | Reference | Reference | Reference | Reference | ||
High | 8.56 | (1.19–61.64) | 0.033* | 1.84 | (0.23–14.52) | 0.565 |
Lymphovascular invasion | ||||||
Negative | Reference | Reference | Reference | Reference | ||
Positive | 7.07 | (4.39–11.38) | < 0.001** | 1.55 | (0.86–2.81) | 0.148 |
