Table.1 The chemical structure of the synthesized compounds and their IC50 values against BChE.

From: Synthesis and biological evaluation of substituted acetamide derivatives as potential butyrylcholinestrase inhibitors

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Compds

R1/R3

BChE: IC50 (μM) ± SEM

Compds

R2

BChE: IC50 (μM) ± SEM

8a

 > 50

13a

 > 50

8b

 > 50

13b

 > 50

8c

3.94 ± 0.15

13c

 > 50

8d

19.60 ± 0.21

13d

 > 50

17a

 > 50

13e

 > 50

17b

 > 50

13f

 > 50

17c

 > 50

13g

 > 50

17d

 > 50

13h

 > 50

   

13i

 > 50

   

13j

 > 50

   

13k

 > 50

Galantamine

/

44.1 ± 0.91

Tacrine

/

0.14 ± 0.01

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