Figure 1 | Scientific Reports

Figure 1

From: Treatment with fibroblast growth factor 19 increases skeletal muscle fiber size, ameliorates metabolic perturbations and hepatic inflammation in 5/6 nephrectomized mice

Figure 1

FGF19 treatment does not modify food intake and body composition in uremic mice. CKD mice induced by 5/6 nephrectomy or Sham mice were treated with 0.1 mg/kg body weight of FGF19 or with vehicle during 18 days. (A) Experimental timeline. (B) Blood urea. (C) 24 h proteinuria. (D) Daily food intake. (E) Body-weight evolution. (F) Body-weight gain. (G) Weight of epididymal WAT. (H) Weight of tibialis anterior, and (I) Weight of soleus (J) Weight of gastrocnemius after FGF19 or vehicle injection. n = 13–15 mice per group expected for proteinuria (n = 5–6). Data are mean ± SEM. Statistical analysis was done using a one-way ANOVA test. *P < 0.05, **P < 0.01, ****P < 0.0001. Abbreviation: BW: body weight, CKD: chronic kidney disease., n.s., not significant; WAT: white adipose tissue.

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