Figure 1
From: Abnormalities in intron retention characterize patients with systemic lupus erythematosus
Intron retention index (IRI) in T and B cells. (A) The density distribution of IRI from all 18 T-cell samples including 4 control samples (green) and 14 SLE patients (gold). (B) Heatmap of pairwise Pearson’s correlation coefficient matrix of IRI distributions shown in (A). There appeared to be two major diagonal blocks separated around L137 with a majority of SLE patients forming the lower block. (C) The density distribution of IRI of all 20 B-cell samples, including 4 control samples (green) and 16 SLE patients (gold). Note that the B cell samples were obtained from a cohort different from that for T cells in (A) above. Namely, T-cell and B-cell samples were not from the same cohort. (D) Heatmap of pairwise Pearson’s correlation coefficient matrix of IRI distributions shown in (C). The lower diagonal block formed by SLE patient samples was clearly separated from the upper block formed by control samples.
