Figure 5
From: Abnormalities in intron retention characterize patients with systemic lupus erythematosus
Volcano plots summarizing the comparison of the splicing ratio of individual intron between SLE patients and control samples in T cells (A) and B cells (B). Fold change of splicing ratio between SLE and control samples was computed and displayed along the x-axis in Log2 scale. Permutation-based p values on the significance of fold change were computed via Mann–Whitney U test and displayed along the y-axis in Log10 scale using 14 SLE versus 4 control samples for T cell and 16 SLE versus. 4 control samples for B cells. Each dot is for one intron. Those introns with |Fo\ldChange|≥ 2.0 (x-axis) and p value ≤ 0.05 (y-axis), i.e., those with significantly altered splicing ratio, were color coded with red for up-regulated (SLE vs. control samples) and blue for down-regulated. Specifically, for T cells in (A), there were 5356 blue dots (from 2617 unique genes) and 120 red dots (from 106 unique genes) out of 30,319 dots in total; and for B cells in (B), 5754 blue dots (from 2839 unique genes) and 533 introns (414 unique genes) out of 11,114 dots.
