Figure 7
From: Coenzyme A binding sites induce proximal acylation across protein families
In-vitro acetylation of ECHS1 with acetyl-CoA is competitively inhibited by CoA at lysines proximal to the CoA-binding site. (a) Acetylation at three sites on bacterially produced recombinant ECHS1 increases in vitro after the addition of acetyl-CoA, and these sites are found near the CoA binding site. This acetylation via exogenous acetyl-CoA is inhibited by adding molar excess of CoA.
