Figure 2
Comparison of nucleotide sequences in the first intron of ABO involving the human + 5.8-kb site and the corresponding regions in chimpanzee, gibbon, and Japanese macaque. (A) Comparison of nucleotide sequences in the first intron of ABO among human, chimpanzee, gibbon, and Japanese macaque. The top line shows the nucleotide sequence of the first intron in human ABO from c.28 + 5005 to c.28 + 8800, and the + 5.8-kb site in human ABO is denoted in red. The other lines represent the nucleotide sequences in chimpanzee, gibbon, and Japanese macaque corresponding to the human genome. Retrotransposons in the human genome are denoted over those lines for human and non-human primates. (B) Comparison of nucleotide sequences between the human + 5.8-kb site and the corresponding sites found in non-human primates. The top line shows the nucleotide sequence of the + 5.8-kb site in human ABO from c.28 + 5624 to c.28 + 6125, and the other lines represent the nucleotide sequences of the sites corresponding to the human + 5.8-kb site from chimpanzee, gibbon, and Japanese macaque. The sequences were deposited in GenBank with accession numbers OP775662 (chimpanzee), OP775663 (gibbon), and OP775664 (Japanese macaque). Nucleotides that are red or underlined indicate single nucleotide variants (SNVs) or deletion in individuals with weak phenotypes such as Am, A3, Bm and B3. The motifs for transcription factor recognition sites are indicated by overbars. For comparison with the nucleotides in human ABO, the substituted nucleotides are shown and horizontal bars denote deletion of nucleotides in those monkeys. Solid circles over nucleotides in the human and monkey sequences indicate single nucleotide polymorphisms (SNPs) or variants. Nucleotide sequences belonging to LTR are highlighted in gray, and those belonging to SINE are highlighted in dark gray.
