Table 2 Detection efficiency comparison of various pathogens by mNGS and clinical conventional testing.
mNGS | Clinical conventional testing | X2 | P | |
|---|---|---|---|---|
Virus | ||||
Detected cases of infection (n,%) | 32 (66.7) | 17 (35.4) | 9.379 | 0.002 |
Positive detection rate of virus strains | 42/46 (91.3) | 19/46 (41.3) | 25.737 | 0.000 |
Detection rate of virus strains not detected by control group | 23/42 (54.8) | 0/19 (0) | 16.702 | 0.000 |
Bacteria | ||||
Detected cases of infection (n,%) | 8 (16.7) | 0 | 6.682 | 0.010 |
Positive detection rate of bacteria strains | 16/16 (100.0) | 2/16 (12.5) | 24.889 | 0.000 |
Detection rate of bacteria strains not detected by control group | 14/16 (87.5) | 0/2 (0) | 7.875 | 0.005 |
Fungi | ||||
Detected cases of infection (n,%) | 10 (20.8) | 8 (16.7) | 0.274 | 0.601 |
Positive detection rate of fungi strains | 10/14 (71.4) | 9/14 (64.3) | 0.164 | 0.686 |
Detection rate of fungi strains strains not detected by control group | 5/10 (50.0) | 4/9 (44.4) | 0.059 | 0.809 |
Atypical pathogen | ||||
Detected cases of infection (n,%) | 5 (10.4) | 0 | 4.444 | 0.035 |
Positive detection rate of atypical pathogen strains | 5/5 (100.0) | 0/5 (0) | 10.000 | 0.002 |
Detection rate of atypical pathogen strains not detected by control group | 5/5 (100.0) | 0 (0) | – | – |
Total detection rate of pathogen strains not detected by control group | 47/73 (64.4) | 4/30 (13.3) | 22.167 | 0.000 |
