Figure 2

Molecular interaction of APP IRE mRNA with IRP1. (A) Cartoon diagram of IRP1 with APP IRE mRNA showing superimposition of docked IRE mRNA (light brown ribbon) with IRP1 (green ribbon) complex. (B) Zoomed cartoon diagram of IRP1 showing interactions between residues of IRP1 and IRE mRNA. (C) Binding cavity of IRP1 occupied by IRE mRNA.