Figure 6 | Scientific Reports

Figure 6

From: Iron response elements (IREs)-mRNA of Alzheimer's amyloid precursor protein binding to iron regulatory protein (IRP1): a combined molecular docking and spectroscopic approach

Figure 6

Kinetic rates for the binding of APP IREmRNA to IRP1 protein. (A) Typical time course of the intrinsic protein fluorescence intensity of IRP1 (0.1 μM final) decrease caused by binding of APP mRNA at varying concentration (0.1, 0.2, 0.5, and 1 μM final). (B) The observed rate constant for the binding of IRP1 to APP mRNA was plotted as a function of increasing concentrations of APP mRNA. The solid line represents the fitted curve for a single exponential function. Residuals for the corresponding fits are shown in the lower panels.

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