Table 2 Thermodynamic parameters of enthalpy (ΔH), entropy (ΔS), and Gibb’s free energy (ΔG) for the interactions of APP IRE mRNA with IRP1.

From: Iron response elements (IREs)-mRNA of Alzheimer's amyloid precursor protein binding to iron regulatory protein (IRP1): a combined molecular docking and spectroscopic approach

Complex

ΔH (kJ/mol)

ΔS (J/mol/K)

ΔG (kJ/mol)

APP IRE mRNA·IRP1

− 25.7 ± 2.5

65.0 ± 3.7

− 46.3 ± 3.2

APP IRE mRNA·IRP1_Fe2+

− 41.4 ± 3.3

2.6 ± 0.2

− 41.1 ± 3.4

  1. ΔG values were calculated using the equation ΔG = ΔH − TΔS at 25 °C.
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