Table 3 Temperature-dependent observed rate constants of APP IRE-mRNA binding to IRP1 with and without Fe2+.

From: Iron response elements (IREs)-mRNA of Alzheimer's amyloid precursor protein binding to iron regulatory protein (IRP1): a combined molecular docking and spectroscopic approach

Complex

kobs (s−1)

Ea

5 °C

10 °C

15 °C

20 °C

25 °C

kJ/mol

APP IRE mRNA·IRP1

74 ± 4.3

141 ± 6.2

215 ± 9.5

292 ± 8.4

341 ± 9.6

52.5 ± 2.1

APP IRE mRNA·IRP1-Fe2+

31 ± 1.6

49 ± 2.5

110 ± 3.7

252 ± 9

365 ± 14

86.0 ± 3.2

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