Table 1 Demographics and clinical baseline characteristics.

From: Clinical significance of serum levels of 14-3-3β protein in patients with stable chronic obstructive pulmonary disease

Characteristic

Original cohort (n = 136)

P

Matched cohort (n = 18)

P

HCs group (n = 63)

Stable COPD

group (n = 73)

HCs group (n = 9)

Stable COPD

group (n = 9)

Sex (M), n(%)

25 (40)

62 (85)

 < 0.001

5 (56)

5 (56)

0.681

Age

(years)

39.95 ± 13.64

66.38 ± 10.15

 < 0.001

55.67 ± 7.43

55.78 ± 5.47

0.972

BMI

(kg/m2)

22.78 ± 3.07

22.10 ± 3.80

0.261

24.11 ± 4.29

23.37 ± 3.98

0.707

Neutrophil ratio

0.58 ± 0.08

0.64 ± 0.11

0.002

0.57 ± 0.10

0.61 ± 0.10

0.473

Neutrophil count

(4 × 109/L)

3.83(2.91–4.58)

4.34(3.48–7.09)

0.002

4.14(2.52–4.62)

3.70(3.39–5.16)

0.730

14-3-3β

(ng/mL)

25.77(18.09–34.41)

40.81(30.98–53.82)

 < 0.001

25.77(22.48–29.04)

36.25(30.12–41.33)

0.003

FVC

(L)

3.27 ± 0.82

2.31 ± 0.86

 < 0.001

3.31 ± 1.10

2.49 ± 0.88

0.102

FVC % pred

(%)

92.96 ± 12.33

71.22 ± 19.82

 < 0.001

98.26 ± 14.55

76.98 ± 19.65

0.019

FEV1

(L)

2.82 ± 0.73

1.32 ± 0.66

 < 0.001

2.74 ± 0.93

1.47 ± 0.69

0.005

FEV1% pred

(%)

94.45 ± 12.91

51.65 ± 22.83

 < 0.001

99.67 ± 13.48

55.21 ± 22.30

 < 0.001

FEV1/FVC

(%)

86.09 ± 5.39

55.78 ± 12.15

 < 0.001

82.95 ± 6.03

57.79 ± 12.62

 < 0.001

FEF25 (L)

1.88(1.10–3.27)

0.24(0.17–0.40)

 < 0.001

1.88(0.85–4.62)

0.31(0.16–0.45)

 < 0.001

FEF25%pred

(%)

85.42 ± 24.02

25.15 ± 19.37

 < 0.001

87.18 ± 29.88

19.67 ± 9.88

 < 0.001

FEF50 (L)

3.75(2.97–4.98)

0.59(0.40–1.30)

 < 0.001

3.24(2.51–5.45)

0.98(0.42–1.86)

 < 0.001

FEF50% pred

(%)

93.86 ± 25.68

25.14 ± 18.58

 < 0.001

102.77 ± 36.35

29.57 ± 21.18

 < 0.001

MMEF (L)

3.30 ± 1.10

0.75 ± 0.70

 < 0.001

3.13 ± 1.39

0.78 ± 0.50

 < 0.001

MMEF% pred (%)

93.23 ± 28.53

24.48 ± 17.73

 < 0.001

102.54 ± 37.04

25.07 ± 14.54

 < 0.001

  1. Results are represented as n, mean with SD or median (IQR). Data were tested by χ2 testing, ANOVA, or Kruskal–Wallis test. HCs Healthy controls; BMI Body mass index; FVC Forced vital capacity; FEV1 Forced expiratory volume in one second; FEV1/FVC The ratio of forced expiratory volume in one second to forced vital capacity; FEF25 Forced expiratory flow 25% of FVC; FEF50 Forced expiratory flow 50% of FVC; MMEF maximal mid-expiratory flow; % pred: % predicted.
  2. A P value of less than 0.05 was statistically significant.
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