Figure 1 | Scientific Reports

Figure 1

From: Oncogenic epidermal growth factor receptor signal-induced histone deacetylation suppresses chemokine gene expression in human lung adenocarcinoma

Figure 1

EGFR-mutated (EGFR-mt) lung adenocarcinoma (LA) exhibits a lower number of CD8+ T cells than LA with wild-type EGFR (EGFR-wt) LA. (A) Comparative analysis of the CD8A mRNA levels in human LA (TCGA, Nature 2014) according to the mutational status of EGFR, ALK, and KRAS. EGFR mt (n = 40; 17%), ALK-mt (n = 19; 8%), and KRAS-mt (n = 83; 36%). *p < 0.01. (B) Comparison of the CD8a-positive cells between EGFR-mt (n = 56) LA and EGFR-wt (n = 84) LA using immunohistochemical analysis (IHC). Mean CD8a-positive cells in three 200 × 200 µm2 areas were calculated for each sample. Vertical bars indicate the mean CD8a cells and the error bars indicate the standard deviation. *p < 0.0001. (C) Representative IHC images. Upper and lower panels indicate EGFR-mt and EGFR-wt LA, respectively. Horizontal scale bar: 200 µm.

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