Figure 3 | Scientific Reports

Figure 3

From: Oncogenic epidermal growth factor receptor signal-induced histone deacetylation suppresses chemokine gene expression in human lung adenocarcinoma

Figure 3

Assay for transposase-accessible chromatin using high-throughput sequencing (ATAC-seq) analysis of the sequences near CXCL9, CXCL10, and CXCL11 in AZD9291-treated EGFR-mutated (EGFR-mt) lung adenocarcinoma (LA) cells. Treatment with AZD9291 generated three open chromatin peaks. One is in the first intron of CXCL9 (+ 159 bp from the transcription start site (TSS)), while the other two are in the 5′ region of CXCL11 (− 15,480 and − 19,130 bp from the TSS) (arrows and rectangle boxes). The large peak at the 15 kb region upstream of CXCL11 comprises three merged peaks.

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