Figure 5 | Scientific Reports

Figure 5

From: Oncogenic epidermal growth factor receptor signal-induced histone deacetylation suppresses chemokine gene expression in human lung adenocarcinoma

Figure 5

Oncogenic EGFR signaling suppressed histone H3K27 acetylation at 15 kb upstream of CXCL11 TSS, which corresponded to the open chromatin peak by ATAC-seq. Histone H3K27 acetylation peaks are represented in Integrative genomic view (IGV). (A) Red histogram (AZD9291-treated) showed a significantly higher peak than blue histogram (DMSO-treated) at chr4:76,050,566–76,051,369 (p = 10–31, q = 10–25) (red rectangle), which overlapped to the open chromatin peak by ATAC-seq at chr4: 76,051,000–76,052,100. (B) Histone H3K27 acetylation peak in the 1st intron of CXCL9 (chr4: 76,007,200–76,007,500) did not show significant difference between AZD9291 and DMSO.

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