Figure 3

Representative images of the subgroup A and B. The left column images (a, b, c, d, and e) represent group B (i.e., good response), while the right column images (f, g, h, i, and j) represent group A (i.e., poor response). Best-corrected visual acuity (BCVA), using the log of minimum angle of resolution and Snellen (parenthesis), is documented on the right upper corner of each image. At baseline, type 1 choroidal neovascularization (CNV) is diagnosed with fluorescein angiography (a and f), indocyanine green angiography (b and g), and optical coherence tomography (c and h). The group B eye has juxtafoveal CNV while the group A eye has subfoveal CNV. Both eyes have similar ONL thicknesses (c and h, 59 µm and 45 µm, respectively) and vision at baseline. After 3 initial monthly loading doses with aflibercept, the subretinal fluid is well resorbed in both the groups; however, the ONL thickness and BCVA recovered in the group B eyes (d, 88 µm), while they remained unchanged in the group A eyes (i, 45 µm). These differences were maintained until the 1-year follow-up (e and j, 88 µm, and 40 µm, respectively). The yellow lines indicate the foveal ONL thickness.