Table 2 Cox proportional hazard model for risk of cataract.
From: Hydroxychloroquine is neutral on incidental cataracts in patients with rheumatoid arthritis
No. of cataract event | Observed person-years | Incidence density (per 1000 person-years) | Crude HR (95% C.I.) | Adjusted HR† (95% C.I.) | |
|---|---|---|---|---|---|
Hydroxychloroquine | |||||
No | 80 | 2775 | 28.8 | 1 | 1 |
Yes | 93 | 2551 | 36.5 | 1.28 (0.95–1.73) | 1.17 (0.86–1.59) |
Age | |||||
20–65 | 140 | 5018 | 27.9 | 1 | 1 |
≥65 | 33 | 309 | 106.9 | 3.89 (2.65–5.69) | 3.15 (2.07–4.80) |
Gender | |||||
Female | 104 | 3439 | 30.2 | 1 | 1 |
Male | 69 | 1888 | 36.5 | 1.21 (0.89–1.64) | 1.21 (0.89–1.65) |
Hypertension | 43 | 763 | 56.4 | 1.98 (1.40–2.79) | 1.29 (0.86–1.93) |
Hyperlipidemia | 19 | 331 | 57.4 | 1.86 (1.16–3.01) | 1.28 (0.76–2.14) |
Chronic liver disease | 13 | 416 | 31.3 | 0.96 (0.55–1.69) | 0.99 (0.55–1.77) |
Chronic kidney disease | 2 | 38 | 52.7 | 1.63 (0.40–6.57) | 0.82 (0.20–3.45) |
COPD | 10 | 159 | 62.8 | 1.99 (1.05–3.77) | 2.02 (1.05–3.91) |
Diabetes | 24 | 243 | 98.6 | 3.38 (2.19–5.22) | 2.59 (1.58–4.24) |
Uveitis | 3 | 52 | 57.2 | 1.78 (0.57–5.58) | 2.68 (0.84–8.56) |
Methotrexate | 76 | 2633 | 28.9 | 0.80 (0.60–1.09) | 1.00 (0.73–1.37) |
Biologics | 5 | 445 | 11.2 | 0.33 (0.14–0.81) | 0.33 (0.13–0.82) |
Ophthalmology | 108 | 3748 | 28.8 | 0.69 (0.51–0.95) | 0.89 (0.64–1.24) |
Corticosteroids | 141 | 4738 | 29.8 | 0.54 (0.37–0.80) | 0.52 (0.34–0.78) |
