Figure 3

Hazard ratios of albuminuria stage for incident end stage kidney disease (ESKD) according to age (with death as a competing risk) in elderly (≥ 65 years) patients with diabetes (a). Albuminuria was a significant risk factor for incident ESKD in patients aged 65–69, 70–74, and ≥ 75 years. The higher the stage of albuminuria was the higher the risk of incident ESKD; this relationship was consistent across the different age groups. The hazards of albuminuria seemed to be attenuated in older groups. The interaction between albuminuria stages and age groups were not significant. Hazard ratios of albuminuria stage for all-cause mortality according to age (b). The increased risk of all-cause mortality with albuminuria was consistent in the three age groups. There were no significant interactions between albuminuria stages and age groups. ^aAdjusted for baseline covariates, including age, sex, body mass index, systolic blood pressure, duration of diabetes, estimated glomerular filtration rate as a continuous variable, glycosylated hemoglobin, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and comorbidities (CVD and heart failure). A1: normoalbuminuria (ACR < 30 mg/gCr), A2: microalbuminuria (ACR 30–300 mg/gCr), A3: macroalbuminuria (ACR > 300 mg/gCr). HR, hazard ratio; CI, confidence interval; ACR, albumin-to-creatinine ratio; CVD, cardiovascular disease.