Table 2 Risk factors of end stage kidney disease in elderly (≥ 65 years) patients with diabetes.

From: Prognostic significance of albuminuria in elderly of various ages with diabetes

Variables

Univariate analysis

Multivariate analysisc

HR (95% CI)

P value

HR (95% CI)

P value

Age, year

1.027 (0.998–1.057)

0.068

  

Female (vs. male)

0.987 (0.719–1.354)

0.936

  

BMI, kg/m2

1.016 (0.959–1.076)

0.589

  

SBP, mmHg

1.042(1.028–1.055)

 < 0.001

1.017 (1.005–1.029)

0.005

Duration of diabetes (per 1 year)

1.049 (1.035–1.064)

 < 0.001

  

ACR < 30 mg/gCr

1

 

1

 

 ACR 30 to 300 mg/gCr

6.407 (3.811–10.772)

 < 0.001

3.650 (1.987–6.702)

 < 0.001

 ACR > 300 mg/gCr

35.068 (21.535–57.105)

 < 0.001

10.404 (5.706–18.972)

 < 0.001

eGFR, ml/min/1.73 m2

0.923 (0.913–0.934)

 < 0.001

0.944 (0.933–0.955)

 < 0.001

HbA1c, %

1.386 (1.233–1.557)

 < 0.001

1.188 (1.039–1.359)

0.012

HDL cholesterol, mg/dl

0.976 (0.962–0.990)

0.001

  

LDL cholesterol, mg/dl

1.004 (0.998–1.010)

0.147

1.006 (1.001–1.011)

0.025

Cardiovascular diseaseab

1.701 (1.211–2.388)

0.002

  

Heart failurea

2.784 (1.507–5.142)

0.001

  
  1. HR, hazard ratio; CI, confidence interval; BMI, body mass index; SBP, systolic blood pressure; ACR, albumin to creatinine ratio; eGFR, estimated glomerular filtration rate; HbA1c, glycosylated hemoglobin; HDL-cholesterol, high-density lipoprotein cholesterol; LDL-cholesterol, low-density lipoprotein cholesterol.
  2. aDefined as a comorbidity that a diagnostic code existed prior to study enrollment.
  3. bMyocardial infarction, cerebrovascular accident, transient ischemic attack, and peripheral vascular disease were combined into a cardiovascular disease based on whether any of the individual comorbidities were present.
  4. cAge, sex, BMI, SBP, duration of diabetes, stage of albuminuria, eGFR, HbA1c, HDL cholesterol, LDL cholesterol, and history of comorbidities (cardiovascular disease and heart failure) were included in the multivariate analysis.
Back to article page