Figure 4

MDV infection shifts cell type composition and gene expression profiles. (A) Cell type composition by infection status within the resistant (ADOL 6₃) or susceptible line (ADOL 7₂). Each cell type is indicated by color according to the key. Within each line, significant differences (p < 0.05) in abundance between the MDV-infected and controls are marked by asterisks on whichever infection status had higher abundance of that cell type. (B) Summary of significant differentially expressed genes (DEGs; |log₂FC|≥ 1.0, p-adj < 0.01) in MDV-infected compared to control for each cell type within the resistant and susceptible lines (total n = 964). The number of DEGs increased by MDV are represented by the red bars (right side of the plot), while DEGs decreased by MDV are shown in blue (left side). The magnitude of log₂FC for the DEGs within each bar is further illustrated by binning into the red-blue color scale.