Figure 5 | Scientific Reports

Figure 5

From: Single-cell analysis reveals novel clonally expanded monocytes associated with IL1β–IL1R2 pair in acute inflammatory demyelinating polyneuropathy

Figure 5

Landscape of monocytes and characteristics of AIDP specific subtype. (a) UMAP visualization of cell clusters after re-clustering monocytes. (b) UMAP visualization of manually annotated cell types of monocytes. (c) A dot plot of top 10 most differentially expressed genes for identified monocyte clusters, the dots of top 10 genes are circled by purple boxes in monocytes clusters. Some genes are overlapped across clusters. Color scale of dots represents the gene expression levels in each cluster, size of dots represents the percentage of cells expressing a gene in each cluster. (d) Distribution of some representative marker genes in monocytes. Color scale represents the gene expression levels in each cell. (e) Proportion of cell types in each group. The colors indicate cell type information. (f) Volcanos of top 20 upregulated and downregulated DEGs between HC and AIDP patients of CD14 + CD163 high monocyte. (g) GSEA-GO enrichment analysis in DEGs of CD14 + CD163 high monocyte. Dot plots display top 20 biological process of GO terms according to P value. (h) GSEA-KEGG enrichment analysis in DEGs of CD14 + CD163 high monocyte. GSEA enrichment plots display top 10 KEGG pathways according to P value.

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