Figure 7

Landscape and characteristics of T cell subsets. (a) UMAP visualization of HC and AIDP patients T cell clusters. The color represents different clusters. (b) Cell annotation of HC and AIDP patients T cell clusters and visualization by UMAP. (c) A dot plot shows the expression of reference marker genes in T cell types, the plot color scale represents the average expression and the size scale represents the expression percent of selected marker gene transcripts in each cell type. The dots of each cell type specific genes are circled by red boxes. (d) Boxplots show proportions of each T cell type in HC and AIDP patients. The x axis correspond to cell types, the y axis correspond to cell counts. Wilcoxon rank-sum test is used to calculate two-sided P values between HC and AIDP patients, shown all P values. Horizontal lines represent median values, with whiskers extending to the farthest data point within a maximum of 1.5 × interquartile range. (e) A volcano of upregulated and downregulated DEGs between HC and AIDP patients in MALAT1 + CD4 + T cells. (f) GSEA-GO enrichment analysis in DEGs of MALAT1 + CD4 + T cells. A dot plot displays top 10 BP, CC and MF of GO terms according to adjust P value. (g) GSEA-KEGG enrichment analysis in DEGs of MALAT1 + CD4 + T cells. A GSEA enrichment plot displays top 10 KEGG pathways according to adjust P value.