Table 1 Data collection and procedures per study visit.

Months from the baseline

0

6

12

18

24

25

Procedure

 Informed consent

X

X

 Eligibility

X

 Medical history

X

 Vital signs and weight

X

X

X

 Anthropometric study (Tanita)

X

X

X

 Neurological examination

X

X

X

X

 Adverse events

X

X

X

X

X

 Concomitant medication

X

X

X

X

X

X

 Medication dispensing

X

X

X

X

 Medication adherence questionnaire

X

X

X

X

Assessment

 Blood drawn and plasma obtention

X

X

X

X

X

X

 Mini-Mental State Examination (MMSE)*

X

X

X

 Clinical dementia rating (CDR)

X

X

X

 Hachinski Ischemic Scale

X

X

X

Neuropsychiatric Inventory Questionnaire (NPI)*

X

X

X

 Global Deterioration Scale (GDS)

X

X

X

 Geriatric Depression Scale

X

X

X

 Blessed Scale

X

X

X

 NBACE**

X

X

X

 HADS***

X

X

X