Figure 3

LBI supplementation reduced the levels of OVA-specific IgE in OVA-induced allergic rhinitis mice. (A, B) The number of IgE⁺B220^-CD45⁺ IgE-producing plasma cells in the nasal passage (A) and IgE⁺B220⁺CD45⁺ IgE-class-switched lymphoblasts in the draining lymph nodes (B). (C) Enzyme-linked immunosorbent assay of OVA-specific IgE. The correlation between IgE levels and nasal symptoms (D: sneezing, E: nasal rubbing) was calculated using Pearson’s test. The data were pooled from two different experiments and are shown as the mean ± SEM (n = 7, 8, 8). One-way ANOVA test with Tukey’s multiple comparisons test (A, B). Kruskal–Wallis test (C). n.s.: not significant; *p < 0.05, **p < 0.01. NP, nasal passage; dLN, draining lymph nodes.