Figure 1 | Scientific Reports

Figure 1

From: Molecular pathways identified from single nucleotide polymorphisms demonstrate mechanistic differences in systemic lupus erythematosus patients of Asian and European ancestry

Figure 1

Mapping the functional genes associated with SLE-Immunochip SNPs. (A) Venn diagram depicting the ancestral overlap of all SLE-associated Immunochip SNPs. (B) Distribution of genomic functional categories for all EA and AsA non-HLA associated SLE SNPs. Genomic category comparisons between ancestral groups were performed using a 2-proportion z test. P values were 2-tailed, and asterisks indicate a significance threshold of p < 0.05. (C) Functional SNP-associated genes are derived from 4 sources, including eQTL analysis (E-Genes), regulatory regions (T-Genes), coding regions (C-Genes) and proximal gene-SNP annotation (P-Genes). (D, E) Venn diagrams showing the overlap of all EA (D) and AsA (E) associated E-, T-, C- and P-Genes.

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