Figure 3 | Scientific Reports

Figure 3

From: Molecular pathways identified from single nucleotide polymorphisms demonstrate mechanistic differences in systemic lupus erythematosus patients of Asian and European ancestry

Figure 3

Key pathways determined by EA and AsA-associated genes. Cluster metastructures for EA (A), AsA (B) and the shared gene cohort (C) were generated based on PPI networks, clustered using MCODE and visualized in Cytoscape. Cluster size indicates the number of genes per cluster, edge weight indicates the number of inter-cluster connections and color indicates the number of intra-cluster connections. Enrichment for each cluster was determined by BIG-C and IPA; clusters were then grouped and categorized according to overall function (immune, tissue repair, metabolic, motility or general). Grey boxes indicate categories lacking relevant clusters. (D) Venn diagram showing the number of overlapping pathways motivated by EA or AsA predicted genes. Representative pathways are listed.

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