Figure 5 | Scientific Reports

Figure 5

From: Molecular pathways identified from single nucleotide polymorphisms demonstrate mechanistic differences in systemic lupus erythematosus patients of Asian and European ancestry

Figure 5

Asian-associated pathways are validated with gene expression data from AsA SLE patients. (A) Using differentially expressed (DE) genes from AsA whole blood samples (E-MTAB-11191), metastructures were generated based on PPI networks, clustered using MCODE and visualized in Cytoscape. Cluster size indicates the number of genes per cluster, edge weight indicates the number of inter-cluster connections and color indicates the number of intra-cluster connections. Enrichment for each cluster was determined by BIG-C and IPA; clusters were then grouped and categorized according to overall function (immune, tissue repair, metabolic, motility [Continued from previous page] or genera cell funtionl. (B) Bar graph showing the precent of associated (EA/AsA immunochip and AsA GWAS), differentially expressed and random genes falling into each overall functional category.

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