Figure 6 | Scientific Reports

Figure 6

From: Molecular pathways identified from single nucleotide polymorphisms demonstrate mechanistic differences in systemic lupus erythematosus patients of Asian and European ancestry

Figure 6

SNP-associated pathways inform gene signatures for GSVA analysis in patient PBMC datasets. GSVA enrichment scores were generated for PBMCs in EA and AsA SLE patients and healthy controls from FDAPBMC1 (EA-only patients and controls) and GSE81622 (AsA-only patients and controls). GSVA scores for type I and type II interferon-based gene signatures (A, B), metabolic gene signatures (C, D), cellular processes (E, F) and individual cell type signatures (G, H) are shown. Asterisks (*) indicate a p-value < 0.05 using Welch’s t-test comparing SLE to control.

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