Table 2 Mean ± standard deviation VASI score at each study and follow-up time point compared among the placebo, monotherapy, and combination therapy groups (ITT analysis).

From: The efficacy of bimatoprost ophthalmic solution combined with NB-UVB phototherapy in non-segmental and segmental vitiligo: a single-blind randomized controlled study

Time point

n

VASI score

p*

Placebo

Bimatoprost 0.01% monotherapy

Bimatoprost 0.01% + NB-UVB

Baseline

19

100.00 ± 0.0

100.00 ± 0.0

100.00 ± 0.0

N/A

1 month

19

100.00 ± 0.0

95.79 ± 8.2

94.74 ± 8.2

0.028b

2 months

19

98.95 ± 3.2

88.95 ± 13.5

88.95 ± 8.4

0.001a,b

3 months

19

96.58 ± 6.7

85.00 ± 19.7

77.63 ± 19.9

0.003b

4 months

19

95.26 ± 11.7

80.26 ± 22.0

64.21 ± 26.8

0.001b

5 months

19

92.11 ± 17.6

75.00 ± 24.2

60.00 ± 25.4

0.001b

6 months

19

90.00 ± 21.0

70.00 ± 26.4

55.79 ± 26.8

0.001b

Follow up at 1 month

19

87.11 ± 23.1

71.05 ± 26.6

55.00 ± 27.9

0.002b

Follow up at 2 months

19

88.42 ± 23.1

72.37 ± 26.2

55.00 ± 27.9

0.002b

  1. VASI score Vitiligo Area Scoring Index score, NB-UVB narrowband ultraviolet B phototherapy, ITT intention to treat.
  2. *Repeated measurement ANOVA with multiple comparison by Bonferroni method; statistical significance defined as p-value < 0.05.
  3. aPlacebo vs monotherapy.
  4. bPlacebo vs combination therapy.