Figure 3
From: Ablation of TRPC3 disrupts Ca2+ signaling in salivary ductal cells and promotes sialolithiasis
Stone-forming phenotype in TRPC3-ablated mice compared to stone patients. Immunofluorescent images of human (A) control and (B, C) salivary gland stone patient SMG tissues. TRPC3 or CaSR localization (Green) was depicted with a yellow arrow. Von Kossa staining images of SMG tissue from (D) salivary gland stone patient and (E) TRPC3 KO mice were acquired with noted calcified areas. (D, E) Calcified region was indicated with a blue arrow. Immunofluorescent images of SMG tissues portraying (F) Control tissue Immunoglobin G (IgG) and secondary antibody (Sec Ab), (G) Control CaSR with SMa counterstaining, and (H) salivary gland stone patient CaSR. Scale bars = 50 µm (A-E) or 35 µm (F-H).
