Figure 5

Simulation of longitudinal signals with an HTT-lowering effect. Two signal levels were used to simulate visits at baseline (Log signal = 1) and at follow-up (Log signal = 0.7), respectively. (a) The Offset model was defined by the random intercepts and fixed slopes that emerged from the Offset model fit to the concentration–response curve data. (b) Percent change plotted against absolute change in the Offset model. (c) The Offset + Slope model was defined by the random intercepts and random slopes that emerged from the Offset + Slope model fit to the concentration–response curve data. (d) Percent change plotted against absolute change in the Offset + Slope model. Legends outline the recombinant HTTs: icon shape denotes the protein size/number of amino acids; icon colour denotes the polyQ-repeat length. BL, baseline; FU, follow-up; HTT, huntingtin protein; polyQ, polyglutamine.