Table 3 Inter-assay precision in the CSF of patients with HD.

From: Quantifying mutant huntingtin protein in human cerebrospinal fluid to support the development of huntingtin-lowering therapies

 

Found mHTT concentration (pg/mL) in patient CSF

Sample 1

Sample 2

Sample 3

Sample 4

Sample 5

Run ID

Roche

ICON

Roche

ICON

Roche

ICON

Roche

ICON

Roche

ICON

Run 1

1.98

3.36

2.60

3.16

3.92

4.26

3.42

5.73

6.83

7.22

Run 2

2.05

2.55

2.55

3.03

3.75

3.83

3.25

3.90

6.28

7.21

Run 3

2.18

3.02

2.82

3.20

4.21

4.18

4.20

4.19

6.40

6.22

n

3

3

3

3

3

3

3

3

3

3

Mean conc. (pg/mL)

2.07

2.98

2.66

3.13

3.96

4.09

3.62

4.61

6.50

6.88

Precision (%CV)

4.9

13.7

5.4

2.9

5.9

5.5

14.0

21.4

4.4

8.3

  1. Conc. Concentration, CSF cerebrospinal fluid, CV coefficient of variation, HD Huntington’s disease, mHTT mutant huntingtin protein.