Figure 1
From: Rational design of phase separating peptides based on phase separating protein sequence of p53
Design concept of artificial PS peptide. (A) Liquid droplet formation of PS peptide and recruitment of a target protein. Peptides (black) dispersed in solution form a liquid droplet, and the target protein (blue) is recruited into the droplet. (B) Scheme of one-by-three design targeting PS protein sequence (pink arrow). This provides the complementary peptide binder sequence and PS residue amplification in the peptide (e.g. 7 R in peptide vs. 4 D plus 1 E in target) for self-PS. p53 N-terminal IDR sequence is displayed as an example of target PS protein. Red and blue characters of sequences correspond to PS residues.
