Table 1 Comparison of baseline characteristics and perioperative parameters between patients treated with sugammadex and with neostigmine before and after adjusting for confounding by sIPTW in the total cohort.

From: Effects of sugammadex versus neostigmine on postoperative nausea and vomiting after general anesthesia in adult patients:a single-center retrospective study

Characteristics

Before sIPTW

After sIPTWa

Sugammadex (n = 5918)

Neostigmine (n = 4994)

SMD

Sugammadex (n = 5928)

Neostigmine (n = 4736)

SMD

Age, years

61 (49–69)

54 (42–64)

0.363

59 (46–68)

57 (45–67)

0.070

Female

3047 (51.5)

3527 (70.6)

0.400

3531.7 (59.6)

3053.4 (64.5)

0.101

Body mass index, kg·m−2

23.9 (21.8–26.3)

23.8(21.6–26.3)

0.025

23.8 (21.6–26.3)

23.8 (21.6–26.2)

0.024

Current smoker

435 (7.4)

328 (6.6)

0.031

434.5 (7.3)

318.7 (6.7)

0.023

History of PONV

151 (2.6)

104 (2.1)

0.031

150.3 (2.5)

121 (2.6)

0.001

ASA physical status I/II/III

752 (12.7)/4505 (76.1)/661 (11.2)

913 (18.3)/3773 (74.7)/348 (7.0)

0.200

918 (15.5)/4422 (74.6)/589 (9.9)

761 (16.1)/3534 (74.6)/441 (9.3)

0.025

Cholecystectomy or gynecological or laparoscopic surgeries

2733 (46.2)

800 (16.0)

0.689

1934 (32.6)

1552 (32.8)

0.003

Extent of surgery, minor/intermediate/major

487 (8.2)/ 384 (6.5)/ 5047 (85.3)

1303 (26.1)/ 1225 (24.5)/ 2466 (49.4)

0.830

1055 (17.8)/ 861 (14.5)/ 4012 (67.7)

856 (18.1)/ 746 (15.7)/ 3134 (66.2)

0.037

Type of general anesthesia

  

0.321

  

0.027

Total intravenous anesthesia

1446 (24.4)

1958 (39.2)

 

1927 (32.5)

1600 (33.8)

 

Inhalation anesthesia

4472 (75.6)

3036 (61.1)

 

3902 (67.5)

3136 (66.2)

 

Intraoperative steroid use

2994 (50.6)

965 (19.3)

0.694

2066 (34.9)

1500 (31.7)

0.068

Intraoperative 5-HT3R antagonist use

5537 (93.6)

3847 (77.0)

0.480

5198 (87.7)

4029 (85.1)

0.076

Intraoperative opioid use

5902 (99.7)

4940 (98.9)

0.099

5887 (99.3)

4704 (99.3)

0.004

Duration of anesthesia, hour

2.65 (1.93–3.83)

2.40 (1.67–3.50)

0.172

2.43 (1.65–3.60)

2.55 (1.77–3.58)

0.025

Postoperative opioid useb

5208 (88)

3230 (64.7)

0.571

4517 (76.2)

3552 (75)

0.028

  1. The values are presented as the medians (interquartile range) or as the numbers (%).
  2. aStabilized weights are used to adjust for confounding. The following variables are used as contributors to the propensity score: age, sex, body mass index, current smoker, ASA physical status, cholecystectomy or gynecological or laparoscopic surgeries, type of general anesthesia, intraoperative steroid use, intraoperative 5-HT3R antagonist use, intraoperative opioid use, and duration of anesthesia. Postoperative opioid use is not used for propensity score calculation.
  3. bDuring the first 24 h postoperatively.
  4. ASA, American Society of Anesthesiologists; SMD, standardized mean difference; sIPTW, stabilized inverse probability of treatment weighting; 5-HT3R, 5-hydroxytryptamine receptor.
Back to article page