Table 1 IC50 values (µM) for the 15 compounds compared to 5-FU on the three colon cancer cell lines.
From: Pyrazole-sulfonamide scaffold featuring dual-tail strategy as apoptosis inducers in colon cancer
Compound | HCT-116 (µM) | HT-29 (µM) | SW-620 (µM) |
|---|---|---|---|
2 | 36.54 ± 1.35* | > 100 | > 100 |
3 | 45.88 ± 1.24* | 28.23 ± 0.97* | 16.57 ± 0.83NS |
4 | > 100 | > 100 | > 100 |
5 | > 100 | > 100 | > 100 |
6 | > 100 | > 100 | > 100 |
7 | > 100 | > 100 | > 100 |
8 | > 100 | > 100 | > 100 |
9 | > 100 | > 100 | > 100 |
10 | > 100 | > 100 | > 100 |
11 | 25.01 ± 2.11* | 8.99 ± 0.56NS | 3.27 ± 0.33* |
12 | 23.33 ± 2.23* | > 100 | > 100 |
13 | > 100 | > 100 | > 100 |
14 | > 100 | > 100 | > 100 |
15 | > 100 | > 100 | > 100 |
16 | > 100 | > 100 | > 100 |
5-FU | 3.7 ± 1.22 | 12.36 ± 0.76 | 14.80 ± 0.66 |
