Table 2 Meta-analysis of the regional prevalence of the hepatitis B virus genotypes.

From: Mapping hepatitis B virus genotypes on the African continent from 1997 to 2021: a systematic review with meta-analysis

Sub-groups

No

Sample size

Analysis of HBV prevalence

*P value

Analysis of heterogeneity

**Phet

Model

Genotype

Prevalence % (95% CI)

I2% (95% CI)

East Africa

 Genotype A

10

531

72.791 (41.7 to 94.86) Ref

 

98.17 (97.55 to 98.63)

< 0.0001

Random

 Genotype B

2

167

1.632 (0.307 to 4.889)

< 0.0001

0.00 (0.00 to 0.00)

0.4183

Fixed

 Genotype C

2

167

15.192 (10.141 to 21.507)

< 0.0001

42.20 (0.00 to 0.00)

0.1884

Fixed

 Genotype D

5

354

19.638 (6.564 to 37.508)

< 0.0001

92.92 (86.43 to 96.30)

< 0.0001

Random

 Genotype E

5

390

15.440 (0.819 to 43.183)

< 0.0001

97.43 (95.85 to 98.41)

< 0.0001

Random

South Africa

 Genotype A

11

453

76.037 (64.091 to 86.206) Ref

 

83.89 (72.69 to 90.49)

< 0.0001

Random

 Genotype B

2

46

12.638 (0.481 to 37.349)

< 0.0001

75.41 (0.00 to 94.43)

0.0437

Random

 Genotype C

2

46

7.720 (2.003 to 19.176)

< 0.0001

10.76 (0.00 to 0.00)

0.2898

Fixed

 Genotype D

8

388

17.248 (10.042 to 25.917)

< 0.0001

67.36 (31.21 to 84.51)

0.0032

Random

 Genotype E

5

328

26.662 (1.717 to 66.518)

< 0.0001

97.32 (95.66 to 98.35)

< 0.0001

Random

West Africa

 Genotype E

29

1629

89.754 (83.381 to 94.724) Ref

 

92.97 (90.97 to 94.53)

< 0.0001

Random

 Genotype A

16

1220

14.999 (7.136 to 25.116)

< 0.0001

95.03 (93.25 to 96.34)

< 0.0001

Random

 Genotype B

2

153

11.832 (2.578 to 57.786)

< 0.0001

93.64 (79.48 to 98.03)

0.0001

Random

 Genotype D

5

328

3.746 (1.979 to 6.387)

< 0.0001

0.00 (0.00 to 79.74)

0.4247

Fixed

North Africa

 Genotype D

7

621

75.074 (58.01 to 88.85) Ref

 

95.07 (92.03 to 96.95)

< 0.0001

Random

 Genotype E

3

157

13.758 (1.353 to 35.991)

< 0.0001

89.54 (71.8 to 96.13)

0.0001

Random

 Genotype C

2

234

4.774 (0.391 to 13.618)

< 0.0001

80.66 (17.29 to 95.48)

0.0230

Random

Genotype B

2

234

9.459 (1.435 to 45.997)

< 0.0001

97.42 (93.53 to 98.97)

< 0.0001

Random

Genotype A

5

507

4.510 (1.530 to 8.958)

< 0.0001

75.52 (39.89 to 90.03)

0.0026

Random

  1. *P value of genotype prevalence with respect to the reference genotype < 0.05 statistically significant.
  2. **Phet < 0.1, the random-effects model was used for heterogeneity analysis.
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