Table 3 The lesion scoring of hepatic tissues of butylated hydroxyl anisole (BHA), potassium sorbate (PS), sodium benzoate (SB), boric acid (BA), or calcium propionate (CP)-treated rats.

Parameter	Treatment
Parameter	Control	BHA	PS	SB	BA	CP
A. Macroscopic appearance
1. Hepatomegaly	−	+++	++	+++	++	++
2. Congestion	−	+++	++	+++	+	++
B. Microscopic appearance
1. Hepatic cords disorganization	−	+++	++	++	++	++
2. Degenerative changes	−	+++	+	++	+++	++
3. Inflammatory cell infiltrations	−	+++	++	++	+++	+
4. Blood vessels congestion and dilatation	−	+++	+++	+++	+	++
5. Bile duct hyperplasia	−	++	++	++	++	+
6. Periportal fibrosis	−	++	+	++	+	+

Control group: received distilled water. BHA group: 0.09 mg/kg b.wt. PS group: received 4.5 mg/kg b.wt. SB group: received 0.9 mg/kg b.wt. BA group: received 0.16 mg/kg b.wt. CP group: received 0.18 mg/kg b.wt. Rats were orally given all food preservatives for 90 days.
−: Absence of lesion; +: Mild; ++: Moderate; +++: Severe damage. N = 10/each group.

Quick links

Search