Table 1 α-Glucosidase inhibition of 4-hydroxyquinolinone hydrazone hybridsa.

From: Synthesis, in vitro α-glucosidase inhibitory activities, and molecular dynamic simulations of novel 4-hydroxyquinolinone-hydrazones as potential antidiabetic agents

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Compounds

R

IC50 (µM)

6a

H

382.6 ± 0.9

6b

2-F

247.0 ± 1.1

6c

4-F

195.3 ± 1.2

6d

4-Cl

131.6 ± 0.3

6e

3-Br

436.7 ± 1.0

6f

4-Br

520.2 ± 1.5

6g

4-NO2

120.5 ± 0.8

6h

4-CH3

136.7 ± 0.5

6i

4-OCH3

259.0 ± 1.0

6j

2-OH

154.8 ± 0.1

6k

3-OH

196.3 ± 0.7

6l

2-OH-5-Br

94.2 ± 1.0

6m

2-OH-5-NO2

93.5 ± 0.6

6n

2,4-OH

187.8 ± 0.3

6o

3-OCH3-4-OH

575.6 ± 0.4

Acarbose

 

752.0 ± 2.0

  1. aData represented in terms of mean ± SD.
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