Table 5 Parameters of the receiver operating characteristic curve and predictive value of miRNAs for diagnosing IgAN. AUC, the area under the ROC curve; CI, confidence interval; PPV, positive predictive value; NPV, negative predictive value. IgAN group, n = 174, Disease control ,n = 100, Normal control, n = 97.

From: Urinary miR-16-5p can be used as a potential marker of endocapillary hypercellularity in IgA nephropathy

 

miR-16-5p

Let-7g-5p

miR-15a-5p

AUC

0.73

0.58

0.70

95% CI

0.679–0.781

0.526–0.643

0.646–0.753

P value

P < 0.0001

P = 0.006

P < 0.0001

Optimal cut-off value

2−ΔCt = 0.324

2−ΔCt = 0.0064

2−ΔCt = 0.0468

Sensitivity (%)

65.9

57.1

72.9

Specificity (%)

66.1

55.7

58.9

PPV (%)

63.3

52.4

60.8

NPV (%)

68.4

58.7

71.1

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