Figure 1
From: Deciphering the spectrum of cutaneous lymphomas expressing TFH markers
Histological presentation of a primary cutaneous marginal zone lymphoma (MZL, case no 6). (A) Clinical presentation as 3 erythematous nodules of the face; (B) (Hematoxylin–Eosin-Saffron (HES), ×2.5): Nodular and diffuse architecture involving all the dermis; (C) (HES, ×20): small hyperchromatic cells associated with histiocytes; (D) (CD20, ×20) and (E) (CD4, ×20): Association of B and T-cells in equal proportions (among 50% of each); (F) (CD23, ×10): Residual germinal centers, underlined by a network of CD23+ follicular dendritic cells; (G–I) (CD138 × 10, kappa/lambda, ×20); Association to numerous monotypic kappa plasma cells located outside of the B-cell nodules; (J) (PD1, ×10), (K) (CXCL13, ×20), and (L) (BCL6, ×10): small T-cells of the background harbor a TFH phenotype (PD1 30%, CXCL13 15%, BCL6 10%, CD10 negative). Proliferative index using Ki67/Mib1 was evaluated a 20% (picture not shown). The diagnosis of MZL was confirmed thanks to the presence of a monoclonal B-cell population. This case displayed no pathogenic variant in TNGS.
