Table 1 Baseline demographics per group. FU follow-up, MMSE Mini-mental state examination, CN cognitively normal, F fast, S slow, A Ambiguous, Comparison group comparison statistics, AD Alzheimer’s disease, DLB dementia with Lewy bodies, FTD frontotemporal dementia, CBD corticobasal degeneration, PSP progressive supranuclear palsy, CI confidence interval, n.s. not significant, dash (–) not measured.
From: Discovery of novel CSF biomarkers to predict progression in dementia using machine learning
Fast | Slow | Ambiguous | CN | Comparison | |
|---|---|---|---|---|---|
Sample size, n | 58 | 76 | 76 | 196 | – |
Type of dementia, n, AD/DLB/FTD/CBD/PSP | 43/8/4/2/1 | 38/21/13/2/2 | 38/18/6/6/8 | – | n.s. |
Age, years, average (SD) | 62.6 (7.9) | 66.7 (7.6) | 68.4 (5.7) | 58 (7.8) | F < S; F < A |
Sex, male/female, n | 38/20 | 50/26 | 55/21 | 123/73 | n.s. |
Education, years (SD) | 12.2 (2.8) | 11.9 (2.9) | 10.8 (2.1) | 12.1 (2.9) | A < F; A < CN |
1st MMSE score, average (SD) | 21.3 (4.3) | 23.4 (3.3) | 23.1 (3.8) | – | F < S; A < A |
Decline in MMSE score per year (95% CI) | –4.5 (− 4.9; − 4.1) | − 0.9 (− 1.1; − 0.6) | − 0.9 (− 1.2; − 0.5) | – | S < F; A < F |
n FU visits, average (SD) | 3.1 (1.2) | 3.8 (2.1) | 3 (1) | – | F < S; A < S |
Cognitive FU time, years, average (SD) | 2.2 (1.1) | 2.8 (1.9) | 2 (1) | – | F < S; A < S |
Survival FU time, years, average (SD) | 5.3 (2.2) | 7.2 (1.9) | 3.6 (1.1) | – | F < S; A < S; |
A < F | |||||
Mortality, N (%) | 35 (60) | 38 (50) | 51 (67) | – | n.s. |
